Advancements in Hormone Receptor-Positive Metastatic Breast Cancer - Episode 5

Managing Elacestrant Treatment: From Patient Selection to Supportive Care

May 8, 2025
Virginia Kaklamani, MD, DSc

,
Megan Kruse, MD

Panelists discuss balancing clinical trial data with real-world patient factors when choosing between treatment options, emphasizing the importance of quality of life alongside cancer control in the second-line setting.

Clinical Brief: Second-Line Treatment Decision Framework

Main Discussion Topics:

Integration of patient factors in treatment selection

Balance between efficacy and quality-of-life considerations

Practical considerations: insurance, copays, administration route

Sequential versus concurrent treatment strategies

Role of shared decision-making in complex treatment landscape

Key Points for Physicians:

Treatment selection requires balance of clinical trial data with patient-specific factors

Consider timing of treatments (when versus if to use each therapy)

Patient preferences regarding administration route can influence decisions

Functional status and treatment urgency guide sequencing strategy

Financial and logistical factors play significant role in real-world decisions

The experts emphasized that second-line therapy decisions require integrating scientific evidence with individualized patient assessment, considering medical and practical factors.