Enhertu Reduces Risk of Invasive Disease or Death in HER2+ Breast Cancer

Glossary:

·Invasive Disease–Free Survival (IDFS): the time a patient lives without the original cancer returning, without a new invasive cancer appearing, and without dying from any cause.

·Overall Survival (OS): the total length of time, usually measured from diagnosis or the start of treatment, that a patient is still alive.

·ECOG Performance Status (PS): a simple scale doctors use to measure how a patient's cancer is affecting their daily energy and ability to perform routine activities.

·Interstitial Lung Disease (ILD): a general term for a group of chronic lung disorders that cause inflammation and scarring of the lung tissue, which can make it hard to breathe.

·Distant Recurrence-Free Survival: the time a patient lives after treatment without the cancer coming back in a part of the body far away from the original tumor site.

·Radiation Pneumonitis: a side effect that causes inflammation and irritation of the lungs, typically occurring weeks to months after receiving radiation therapy to the chest area.

·Anemia: a common condition where the blood doesn't have enough healthy red blood cells to carry adequate oxygen from your lungs to the rest of your body, often leading to fatigue.

·Increased Aspartate Aminotransferase Levels (AST): a finding on a blood test that shows a higher-than-normal amount of the AST enzyme, which is often a sign of damage or irritation to the liver or other organs like muscle or heart.

·Increased Alanine Aminotransferase Levels (ALT): a finding on a blood test that shows a higher-than-normal amount of the ALT enzyme, which is a common indicator of liver injury or inflammation.

·Arthralgia: the medical term for pain or stiffness experienced in one or more joints, such as the knees, elbows, or wrists.