Ashling Wahner

PD-L1 expression levels were found to predict improved outcomes with Opdivo and Yervoy in patients with ccRCC, while high KIM-1 levels were associated with worse outcomes.

PD-L1 expression levels were found to be predictive of improved outcomes with Opdivo (nivolumab) and the CTLA-4 inhibitor Yervoy (ipilimumab) in patients with clear cell renal cell carcinoma (ccRCC), whereas high KIM-1 expression led to worse outcomes in this patient population with Opdivo alone or with Yervoy, according to findings from the phase 3 CheckMate 914 trial presented at the 2024 SITC Annual Meeting.

Data showed that high KIM-1 levels were associated with worse disease-free survival (DFS) with Opdivo monotherapy versus placebo in patients with ccRCC, as well as a trend toward poor DFS with Opdivo and Yervoy, suggesting that micro-metastatic disease releases KIM-1 into the circulation, as well as that serum KIM-1 is a potential minimally invasive biomarker for resected RCC recurrence. However, KIM-1 levels were not found to be predictive of response to Opdivo alone or with Yervoy versus placebo.

When DFS was evaluated across study groups stratified by patients with PD-L1 expression lower than 1% (663 patients) and 1% or higher (87 patients), results showed that PD-L1 expression was determined to be predictive of response to Opdivo and Yervoy. Higher baseline PD-L1 levels were significantly associated with better DFS, showing consistency with results from the phase 3 KEYNOTE-564 trial of adjuvant Keytruda (pembrolizumab) in patients with RCC.

However, patients who had higher fibroblast levels within the tumor microenvironment had shorter DFS with Opdivo plus Yervoy compared with Opdivo alone.

Disease-free survival (DFS): the length of time a patient remains free of cancer or disease after treatment.

Overall survival (OS): the length of time a patient survives after being diagnosed.

Tumor microenvironment: the surrounding area of a tumor

Immune checkpoint inhibitors: they help the immune system recognize and attack cancer cells.

Biomarkers: indicators that can signal a condition or the effect of treatment.

“In the adjuvant setting, tumor PD-L1 expression is potentially predictive of favorable [Opdivo] plus [Yervoy] outcome, while high circulating KIM-1 levels are prognostic of worse clinical outcomes,” co-first study authors Sai Vikram Vemula, precision medicine/biomarker lead of immuno oncology at Bristol Myers Squibb, and Dr. Wenxin (Vincent) Xu, an assistant professor of medicine at Harvard Medical School/Dana-Farber Cancer Institute in Boston, Massachusetts, wrote alongside coinvestigators in a poster presented during the meeting. “Patients with PD-L1 expression may be enriched with immune cell populations, contributing to better immunotherapy response.”

Rationale and Design of This Biomarker Analysis

An unmet need exists for predictive biomarkers for immune checkpoint inhibitors in the treatment of patients with ccRCC. Prior data from part A of the CheckMate 914 trial showed that PD-L1 expression and serum KIM-1 levels are independently associated with treatment effect from Opdivo combined with Yervoy versus placebo in patients with localized ccRCC.

In the analysis presented at the 2024 SITC Annual Meeting, investigators further evaluated the role of PD-L1 and KIM-1 for association with Opdivo alone and with Yervoy in part B of the CheckMate 914 trial; they also explored a novel human-interpretable image feature–based platform to characterize the cell and tissue composition from hematoxylin and eosin whole-slide images. This was to assess the platform’s potential to identify novel prognostic and predictive biomarkers for immunotherapy response in RCC.

Part B of CheckMate 914 comprised 825 patients with RCC with predominant clear cell histology. Patients could not have any clinical or radiological evidence of residual disease or distant metastases after nephrectomy.

The median follow-up was 27 months. Additional results showed that serum KIM-1 levels were linked with age and nephrectomy status. Higher levels of KIM-1 were more commonly reported in those who were older than 65 years of age and had undergone partial nephrectomy.

Investigators also explored the association of on-treatment changes in KIM-1 with response to Opdivo alone and with Yervoy. Results showed that on-treatment increase in circulating KIM-1 was linked with shorter DFS, suggesting that KIM-1 could be an early predictor for response to single-agent Opdivo and Opdivo plus Yervoy in this setting.

Furthermore, patients with PD-L1 expression levels of 1% or higher had higher levels of macrophages, lymphocytes and neutrophils, which are all types of white blood cells, indicating a potentially inflamed tumor microenvironment; endothelial cell levels were also lower in this subgroup.

The primary end point was DFS for Opdivo versus placebo, and secondary end points were DFS for Opdivo versus Opdivo/Yervoy, overall survival (OS) for Opdivo versus placebo, OS for Opdivo versus Opdivo/Yervoy and safety.

The authors concluded that these observations should be explored in further clinical trials.

"Integrative biomarkers analysis from the Phase 3 CheckMate 914 trial of nivolumab plus ipilimumab or nivolumab versus placebo for adjuvant clear cell renal cell carcinoma (ccRCC)" by Dr. Vemula SV, et al., presented at: 2024 SITC Annual Meeting; November 6-10, 2024; Houston, TX.

"Overall survival with adjuvant pembrolizumab in renal-cell carcinoma" by Dr. Choueiri TK, et al., 

"Adjuvant nivolumab plus ipilimumab versus placebo for localized renal cell carcinoma after nephrectomy (CheckMate 914): a double-blind, randomised, phase 3 trial" by Dr. Motzer RJ, et al., 

For more news on cancer updates, research and education, don’t forget to 

subscribe to CURE®’s newsletters here.

Articles

PD-L1 expression levels are predictive of improved outcomes with nivolumab and ipilimumab in clear cell renal cell carcinoma (ccRCC), while high KIM-1 expression correlates with worse outcomes. The CheckMate 914 trial revealed that high KIM-1 levels are linked to poor disease-free survival (DFS) with nivolumab, suggesting KIM-1 as a potential biomarker for RCC recurrence. PD-L1 expression is associated with better DFS, consistent with previous trials. High fibroblast levels in the tumor microenvironment correlate with shorter DFS when treated with nivolumab and ipilimumab.

PD-L1 expression was found to predict better outcomes with Opdivo and Yervoy in patients with ccRCC, while high KIM-1 levels were linked to worse outcomes.

PD-L1, KIM-1 Levels May Predict Kidney Cancer Response to Opdivo, Yervoy

Darzalex Regimen Boosts Rates of MRD Negativity in Newly Diagnosed, Transplant-Eligible Myeloma

Darzalex (daratumumab) plus Velcade (bortezomib), Revlimid (lenalidomide) and dexamethasone (D-VRd), followed by autologous stem cell transplant (ASCT), D-VRd consolidation (treatment after ASCT) and Darzalex plus Revlimid (DR) maintenance improved rates of sustained minimal residual disease (MRD; measure of remaining cancer cells after treatment) negativity compared with VRd induction, ASCT, VRd consolidation and Revlimid maintenance in transplant-eligible patients with newly diagnosed multiple myeloma, according to updated data from the phase 3 PERSEUS trial.

Findings, which were presented at the 2024 SOHO Annual Meeting, showed that among patients in the D-VRd arm (355 patients), 57.5% were MRD negative at a 10

sensitivity (extremely low) at the end of consolidation vs 32.5% of patients in the VRd arm (354 patients). In the experimental arm, the MRD-negative rates at the 10

 threshold at up to 12 months, up to 24 months, and up to 36 months were 65.1%, 72.1% and 74.6%, respectively. These respective rates were 38.7%, 44.9% and 46.9% in the control arm.

sensitivity, the MRD-negativity rates (no detectable cancer cells) in the D-VRd arm at the end of consolidation, up to 12 months, up to 24 months and up to 36 months were 34.4%, 43.9%, 57.7% and 63.9%, respectively. In the VRd arm, these respective rates were 16.1%, 20.9%, 27.4% and 30.8%.

D-VRd significantly increased MRD negativity rates.

Patients receiving D-VRd maintained MRD-negative status longer.

D-VRd outperformed VRd in reducing residual cancer cells and improving survival.

D-VRd could become a new standard of care for transplant-eligible patients.

Treatment was tailored to individual patients' MRD status.

Furthermore, 64.8% of patients in the D-VRd group sustained MRD negativity at the 10

threshold for at least 12 months compared with 29.7% of patients in VRd arm. The rates of patients who sustained MRD negativity for at least 18 months at 10

 were 59.4% and 25.1%, respectively. At a 10

 sensitivity, 47.3% of patients in the D-VRd arm sustained MRD negativity for at least 12 months vs 18.6% of patients in the VRd arm. The respective rates of patients who sustained MRD negativity for at least 18 months in these arms were 42% and 15%.

“These data further highlight the benefit of D-VRd and DR maintenance as a new standard of care for transplant-eligible patients with newly diagnosed multiple myeloma,” presenting study author Dr. Meletios A. Dimopoulos said during the presentation.

A New Treatment Option for Transplant-Eligible, Newly Diagnosed Myeloma

 for induction and consolidation in patients with newly diagnosed multiple myeloma who are candidates for ASCT, based on prior data from PERSEUS.2

Previous findings demonstrated that D-VRd reduced the risk of disease or death by 58% compared with VRd alone. The 48-month progression-free survival (PFS; how long a patient with cancer lives without their disease getting worse) rate was 84.3% with D-VRd vs 67.7% with VRd.

The phase 3 study included patients 18 to 70 years of age with newly diagnosed multiple myeloma who were eligible for ASCT.

Patients were randomly assigned to a specific treatment prior to the start of induction therapy. In the control arm, patients received VRd prior to ASCT. Those in the experimental arm received Darzalex plus the same VRd regimen prior to transplant. Induction therapy was given for four 28-day cycles. After ASCT, D-VRd or VRd were administered at the same dosages for two additional cycles.

During ongoing treatment, patients in the control arm received Revlimid until disease progression. In the experimental arm, ongoing therapy was based on MRD status; all patients initially received Darzalex plus Revlimid for a minimum of two years. Patients who were MRD positive continued DR. Those who were MRD negative for at least 12 months and achieved a complete response (CR; when a person's disease cannot be detected by any tests or examinations) or better continued with Revlimid alone; they were permitted to restart Darzalex if they lost their CR without progressive disease or became MRD positive.

PFS served as the trial’s primary outcome. Secondary outcomes included overall CR or better rate, overall MRD-negativity rate and overall survival (OS; the time from the start of treatment when a patient with cancer is still alive).

Subgroup analyses showed that D-VRd improved MRD-negativity rates and sustained MRD-negativity rates compared with VRd across predefined groups.

The overall stringent CR (sCR; a more rigorous standard compared with traditional CR), CR, very good partial response (VGPR; cancer shrank significantly but still present) and PR rates in the D-VRd arm were 69.3%, 18.6%, 7.3% and 1.4%, respectively. These respective rates were 44.6%, 25.4%, 19.2% and 4.5% in the control arm. The CR or better rate was 87.9% in the D-VRd arm vs 70.1% in the VRd arm.

In the D-VRd arm, the respective sCR, CR, VGPR and PR rates at the end of induction were 9.6%, 13%, 62.3% and 9.3%. After ASCT, these rates were 10.7%, 17.2%, 57.5% and 8.7%, respectively. At the end of induction, the sCR, CR, VGPR and PR rates were 18.9%, 25.6%, 46.5% and 4.2%, respectively.

For the VRd arm, the sCR, CR, VGPR and PR rates at the end of induction were 7.1%, 14.1%, 51.4% and 18.1%, respectively. After ASCT, these respective rates were 8.2%, 15.3%, 50% and 17.5%. Following consolidation, the sCR, CR, VGPR and PR rates were 13%, 21.8%, 47.5% and 9.9%, respectively.

Among patients with high-risk disease, those treated with D-VRd (76 patients) achieved an MRD-negativity rate of 68.4% at the 10

 threshold. Those rates were 47.4% and 30.8%, respectively, among patients with high-risk disease in the VRd arm (78 patients). In the experimental arm, 48.7% of patients maintained MRD negativity at a 10

sensitivity for at least 12 months and 30.3% remained MRD negative at the 10

threshold for at least 12 months. Those respective rates were 25.6% and 14.1% in the control arm.

D-VRd (44 patients) also trended toward improved PFS among patients with high-risk disease who achieved MRD negativity at a 10

sensitivity compared with those treated with VRd (24 patients)

Among patients in the D-VRd arm who were MRD positive at the end of consolidation (88 patients), 60.2% became MRD negative at the 10

threshold during maintenance compared with 40.5% of patients treated with VRd (121 patients). At the 10

threshold, these rates were 56.7% for D-VRd (134 patients) and 25.2% for VRd (155 patients). Among patients who became MRD negative at a 10

 sensitivity, 38.6% in the D-VRd arm had sustained MRD negativity vs 17.4% in the control arm. At the 10

 sensitivity, these respective rates were 31.3% and 10.3%.

 sensitivity was associated with improved long-term outcomes in both arms. Overall, 65.1% of patients in the D-VRd arm reached MRD negativity at the 10

threshold at any point compared with 32.2% of patients in the VRd arm.

“The percentage of patients achieving MRD negativity with D-VRd was significantly higher. This again speaks in favor of administering [D-VRd] up-front in order to increase the number of patients who will achieve MRD negativity, sustained MRD negativity, improved PFS and hopefully improved OS,” Dimopoulos concluded.

A Darzalex-based regimen improved MRD negativity rates compared with VRd in patients with newly diagnosed, transplant-eligible multiple myeloma.

Darzalex Regimen Boosts Rates of MRD Negativity in Newly Diagnosed, Transplant-Eligible Myeloma 

Conjugated equine estrogen was associated with higher gynecologic cancer death rates in certain patients.

For patients with ovarian and endometrial cancer, receiving conjugated equine estrogen (CEE; a drug that includes estrogen hormones to treat menopause symptoms) alone was associated with significantly increased cancer-related mortality rates, compared with placebo (inactive treatment) in postmenopausal women who had undergone a prior hysterectomy (surgical removal of the uterus), according to 20-year follow-up data from 2 Women’s Health Initiative (WHI) clinical trials presented during a 

Findings from another randomized study also found that in postmenopausal women with a uterus, CEE in combination with medroxyprogesterone acetate (MPA; menopausal hormone therapy) was not associated with increased ovarian cancer mortality versus placebo — a finding that contrasted data from prior observational studies.

In 2023, endometrial and ovarian cancer accounted for 13,030 and 13,270 deaths, respectively, in the United States, according to a study published in 

“CEE and MPA were approved [as] hormone therapy in the United States [US] in 1943, and the question about endometrial and ovarian cancer has since remained unsettled after nearly 50 years of follow-up,” Dr. Rowan T. Chlebowski, said during the press briefing.

Chlebowski is an investigator at The Lundquist Institute, as well as chief of the Division of Medical Oncology and Hematology at the Harbor-University of California, Los Angeles (UCLA) Medical Center and a professor of medicine at the David Geffen School of Medicine at UCLA.

 included data from two randomized, placebo-controlled, WHI clinical trials that were conducted at 40 clinical centers in the US and enrolled patients from 1993 to 1998. The first trial enrolled 10,739 postmenopausal women who had undergone a prior hysterectomy and received either CEE or placebo.

The second trial enrolled 16,608 postmenopausal women with an intact uterus who received either CEE plus MPA or placebo. Patients were eligible for inclusion in either study if they were 50 to 79 years of age and had no history of breast cancer, with protocol-mandated annual mammogram findings that were not suggestive of breast cancer and endometrial biopsies that were not suggestive of endometrial cancer.

“We only did a study with endometrial cancer in the women who got CEE plus MPA because we had previously known about the increased risk of endometrial cancer in women getting estrogen alone,” Chlebowski noted.

In the CEE-alone trial, ovarian cancer developed in 35 patients who received CEE alone, compared with 17 of those who received placebo. In these respective populations, ovarian cancer mortality occurred in 25 and nine patients, and death from all causes after ovarian cancer occurred in 30 and 12 patients.

“This is the first randomized clinical trial with evidence to indicate that ovarian cancer mortality is increased by [use of] estrogen alone,” Chlebowski emphasized.

In the CEE-plus-MPA trial, ovarian cancer developed in 75 patients who received CEE plus MPA versus 63 of those who received placebo. In these respective populations, ovarian cancer mortality occurred in 65 and 52 patients. Death from all causes after ovarian cancer occurred in 68 and 48 patients.

Endometrial cancer developed in 106 patients who received CEE plus MPA versus 140 of those who received placebo. In these respective populations, endometrial cancer mortality occurred in 13 and 21 patients, and death from all causes after endometrial cancer occurred in 51 and 72 patients.

“These findings inform decisions regarding hormone therapy use and suggest reconsideration of guideline recommendations regarding [the use of] estrogen alone in [postmenopausal women],” Chlebowski concluded.

Postmenopausal patients with ovarian or endometrial cancer who received conjugated equine estrogen may have increased mortality rates. 

Conjugated Equine Estrogen Increases Gynecologic Cancer Death Rates

Patients with blood cancer who were given Orca-T to prevent post-transplantation graft-versus-host disease (GVHD) tended to have better survival than those treated with post-transplant cyclophosphamide (PTCy), according to recent findings presented at the 2024 Transplantation & Cellular Therapy Meetings.

Of note, all patients had matched unrelated donors and were undergoing myeloablative conditioning (MAC), which delays an immune response to the donor cells.

Compared to traditional post-transplant cyclophosphamide (PTCy), Orca-T tends to result in better survival rates and lower rates of post-transplant complications.

The study, presented at the 2024 Transplantation & Cellular Therapy Meetings, found that Orca-T led to a 77% relapse-free survival rate and a 94% overall survival rate, compared to 62% and 77% respectively with PTCy.

These findings highlight the importance of identifying effective treatments to improve outcomes for patients undergoing stem cell transplantation, where over 40% face mortality within three years due to various complications.

Ongoing research, including the Orca Precision-T trial, aims to further evaluate Orca-T's effectiveness in different patient populations and refine its use in clinical practice.

The relapse-free survival (RFS; time patients lived without experiencing relapse) rate was 77% in the cohort of patients who received Orca-T vs 62% in the cohort of patients who received PTCy. Furthermore, the non-relapse mortality (NRM; post-transplant death without relapse or recurrent diseaes) rates with Orca-T and PTCy were 3% and 16%, respectively, and the overall survival (OS; percentage of patients who are still alive) rates were 94% and 77%, respectively.

“The positive impact [of Orca-T] on RFS, NRM and OS highlight the importance of identifying treatment approaches that may be beneficial across all key transplant outcomes in addition to the reduction of [chronic] GVHD,” Dr. Alexandra Gomez Arteaga, lead study author and an assistant professor of Medicine in the Division of Hematology and Medical Oncology at Weill Cornell Medicine/New York-Presbyterian Hospital in New York, New York, stated in the presentation.

Although progress has been made in the treatment of patients with hematologic malignancies requiring allogeneic stem cell transplantation, over 40% of patients who receive allogeneic hematopoietic stem cell transplant (HSCT) die within the first three years of receiving this treatment, with most deaths caused by primary relapse (53%), infection (14%), GVHD (13%) and organ failure (13%). However, Orca-T cell therapy may improve clinical outcomes for these patients.

In the phase 3 BMT CTN 1703 trial, significantly higher GVHD-free RFS rates were observed with PTCy/mycophenolate mofetil/tacrolimus prophylaxis compared with standard prophylaxis in patients who received reduced-intensity conditioning.In the myeloablative setting, however, outcomes in the PTCy arm were not different than those with tacrolimus plus methotrexate. Despite these findings, the use of PTCy in the MAC setting has increased, and NRM and relapse risk continue to be drivers of PTCy progression.

This retrospective study compared historical outcomes with Orca-T vs PTCy in patients who received peripheral blood stem cell (PBSC) grafts and MAC. The Orca-T cohort (111 patients) used clinical data from a multicenter phase 1b trial of Orca-T plus single-agent tacrolimus, which had primary end points of the incidence and timing of primary graft failure and the incidence and timing of moderate to severe (grade 3/4) acute GVHD.

Patients were at least 18 years of age, with a median age of 49 years (range, 20-65). Primary diseases included acute leukemia in complete remission (CR; no detectable disease) or CR with incomplete hematologic recovery (CRi; acute myeloid leukemia [AML; 45.9%], acute lymphoblastic leukemia [ALL; 33.3%], and mixed phenotype [1.8%]), myelodysplastic syndrome (MDS; 15.3%), or chronic myeloid leukemia (CML; 3.6%) treated with Orca-T between 2019 and 2022.

Patients were required to have 8/8 matched related or unrelated donors, and 50.5% of patients had matched related donors. Forty-seven percent of patients were female, and patients had a hematopoietic cell transplantation–specific comorbidity index (HCT-CI; a scale used to predict prognosis) of up to 4 and a Karnofsky performance score (KPS) of at least 70, indicating that they can do most of their daily tasks independently. The median follow-up in this trial was 17 months.

Investigators found no difference in outcomes between matched unrelated donors and matched sibling donors with Orca-T in this trial.

Data from patients who underwent Orca-T treatment were compared to another cohort (83 patients), which consisted of data from a publicly available dataset from the Center for International Blood & Marrow Transplant Research (CIBMTR) database, which included 284 MUD transplantations with PTCy GVHD prophylaxis.

Patients were at least 18 years of age, with a median age of 52 years (range, 18-71). Primary diseases included ALL (26.5%), AML (49.4%), and MDS (24.1%). Forty-nine percent of patients were female, and all patients had 8/8 matched unrelated donors. The primary end point of this dataset was OS, and patients had a median follow-up of 12 months. The limitations to this CIBMTR dataset were that it included only matched unrelated donors, the treatment time frame was from 2011 to 2018, and the incidence of chronic GVHD (cGVHD) was not reported by grade, so investigators were unable to delineate the percentages of moderate and severe GVHD in this population.

The key outcomes assessed in this retrospective analysis were RFS, NRM and OS.

In the myeloid subgroup of the Orca-T cohort (48 patients), the median age was 54 years (range, 20-64) and the median follow-up was 15 months. Forty-eight percent of patients were female, and 58% had HLA-matched related donors. Additionally, 77.1% had ALL and 22.9% had MDS.

In the myeloid subgroup of the PTCy cohort (61 patients), the median age was 57 years (range, 20-71) and the median follow-up was 12 months. Forty-nine percent of patients were female, and 100% had HLA-matched unrelated donors. Additionally, 67.2% had ALL and 32.8% had MDS.

In the myeloid subgroups of the Orca-T and PTCy cohorts, the respective RFS rates were 86% and 63%, the respective NRM rates were 0% and 17%, and the respective OS rates were 100% and 76%.

Investigators found that older age was associated with higher NRM rates with PTCy but not with Orca-T. At 12 months, the NRM rates in patients with myeloid diseases who were younger than 55 years of age were 0% and 8.5% in the Orca-T and PTCy subgroups, respectively. These rates were 0% and 24%, respectively, in patients with myeloid diseases who were older than 55 years of age.

Limitations of this research include its retrospective, nonrandomized design. In the future, investigators plan to evaluate Orca-T vs PTCy in the MAC setting in contemporary homogenous patient populations that include 8/8 matched related and unrelated donors and comparable PBSC donor sources.

Long-term follow-up of this future research at two years and beyond will further demonstrate the differences in key clinical outcomes between treatment with Orca-T and PTCy, including relapse, GVHD, infections, organ toxicities, engraftment syndrome and length of hospitalization and hospital readmissions.

“Acknowledging the limitations of historical comparisons and retrospective analyses, Orca-T could potentially provide improved outcomes as compared with PTCy-based MAC with PBSC graft in patients with acute leukemia or MDS,” Gomez-Arteaga concluded.

The randomized phase 3 Orca Precision-T trial is currently enrolling patients across the United States with undifferentiated AML, ALL or mixed-phenotype acute leukemia who are in CR or CRi to their last line of therapy, as well as patients with high-risk, therapy-related MDS, including those with active disease at the time of transplant. Patients must be planned to undergo myeloablative allogeneic HSCT including one of the following MAC regimens: busulfan plus fludarabine and thiotepa, total body irradiation (TBI) plus etoposide, or TBI plus cyclophosphamide. Additionally, patients must be ages 18 to 65 and have an 8/8 matched related or unrelated donor, an HCT-CI of up to 4, a KPS of at least 70, and adequate organ function.

Patients will be randomly assigned to receive either Orca-T plus single-agent tacrolimus prophylaxis (87 patients) or standard unmanipulated allograft plus dual-agent tacrolimus and methotrexate prophylaxis (87 patients). cGVHD-­free survival will serve as the primary end point of the trial, and secondary end points will include GVHD-free RFS, moderate-to-severe cGVHD and RFS.

Orca-T outperformed post-transplant cyclophosphamide when it came to relapse-free survival and overall survival in patients with blood cancer who underwent a stem cell transplantation from a matched unrelated donor. 

Ashling Wahner

PD-L1, KIM-1 Levels May Predict Kidney Cancer Response to Opdivo, Yervoy

Darzalex Regimen Boosts Rates of MRD Negativity in Newly Diagnosed, Transplant-Eligible Myeloma

Conjugated Equine Estrogen Increases Gynecologic Cancer Death Rates

Orca-T Improves Post-Transplant Survival in Patients With Blood Cancers

Latest News