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Jorge E. Cortes, MD, details clinical scenarios that indicate a need to switch therapies for patients with chronic myeloid leukemia.

CML Treatment: Scenarios that Necessitate Switching Therapy

This program was made possible with support from Novartis Pharmaceuticals.

Video content above is prompted by the following:

In which scenarios do you consider switching CML therapies, and how do you approach that conversation with patients? How does the patient experience change when switching therapies?

Leukemia

 affects the body’s ability to form blood tissue correctly. It also affects the bone marrow and the lymphatic system. White blood cells are one of the body’s main defenses against infection, but those that suffer have bone marrow that produces abnormal white blood cells that are unable to fight infection effectively. Depending on the type and specific diagnosis a stem cell transplant may be recommended.

 – There are four main categories of Leukemia: Acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The main differences in these categories are where cancer began and how quickly it grows or spreads in the body. Acute myeloid leukemia is the most common form of acute Leukemia. In this disease, certain cells found in the bone marrow, called blast cells, do not mature correctly. The cells are still formed but are not able to ward off infection as non-diseased blast cells normally would.

 – Researchers cannot point to an exact cause but it is currently thought to arise from a combination of environmental and genetic factors. Some unknown type of mutation occurs at the cellular level causing the mutated cells to spread throughout the body. Smoking, working with chemicals, such as Benzene, previous cancer treatment (chemotherapy and radiation), are all risk factors.

 – Symptoms are often vague making it difficult to spot. If you have any of the following signs and symptoms especially for a prolonged period it is a good idea to consult a doctor: weight loss you can’t explain, fatigue, reoccurring infections, unexplained bruising, bleeding easily, bone pain, bone tenderness, recurring nosebleeds, fever or chills (unrelated to another illness), sweating, or swollen lymph glands.

Cancer Horizons strives to gather information about leukemia and present it in plain and understandable terms. If you have an article or other content to refer to us or wish to contribute content please 

CURE Expert Connections

Optimizing CML Management: Shared Decision Making and Enhancing the Patient Experience

CURE Expert Connections® is a video series designed to help patients and their loved ones along their cancer care journey by offering information and expert advice from leaders in oncology care. Expert medical professionals share their knowledge and insights on an array of topics to allow for a better understanding of what to expect following a cancer diagnosis. Expert Connections hopes to bridge the gap between patients and oncology professionals to ensure no question is left unanswered.

CML Treatment: Scenarios that Necessitate Switching Therapy

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