A Trailblazer in Oncology Nursing and Research

Gayle S. Jameson, M.S.N, ACNP-BC, AOCN, an oncology nurse practitioner at HonorHealth Research Institute (HRI), is a trailblazer whose extraordinary expertise and compassion have made a profound impact on oncology care and research.

With more than 40 years of experience, including certification as an advanced oncology nurse, Gayle exemplifies professionalism and vast knowledge in every aspect of her work, leaving an indelible mark on her patients, colleagues and the future of oncology.

At HRI, Gayle has championed the role of nurse practitioners as principal investigators (PIs) for phase 1 clinical trials, traditionally a physician-led role. In her role as associate clinical investigator, she has been the PI on 14 phase 1, 2, and investigator-initiated studies. In addition, she has been a subinvestigator on hundreds of phases 1 and 2 antitumor clinical trials. She incorporates translational science into clinical trial designs by working with bench science colleagues at the Translational Genomics Research Institute, Princeton University, Mayo Clinic and Salk Institute for Biological Studies. Gayle also was the site principal investigator on an international study that led to the approval of Onivyde (nanoliposomal irinotecan) plus fluorouracil and leucovorin for patients with metastatic pancreatic cancer.

In 2020, she published results of a study in JAMA Oncology that demonstrated significant improvement in the overall survival of patients with advanced pancreatic cancer. Gayle’s expertise has been showcased in more than 30 published articles, including book chapters, and more than 35 abstracts. As an international speaker, her influence extends globally, further cementing her leadership in oncology research and care.

Gayle’s professional achievements are remarkable, but her deep compassion and empathy for patients are what truly set her apart. A poignant example of her compassionate care is reflected in the story of a patient with newly diagnosed stage 4 pancreatic cancer. This patient, who was raising his sister’s two children, was understandably overwhelmed by his diagnosis and uncertain about his future. Gayle spent hours with him, carefully explaining his diagnosis, offering emotional support and answering his questions. She went above and beyond by connecting him with other patients with pancreatic cancer who shared their experiences, giving him a sense of community and, more importantly, hope. Through these conversations and her guidance, Gayle helped him to realize that he wasn't just another statistic. She helped him find hope and a plan.

This is just one small example of the ways she goes above and beyond in all that she does, truly putting the patient first. This is also a great example of how Gayle cares for her patients comprehensively, not just focusing on the cancer diagnosis, but also taking into account other factors that are often a burden for patients. This emotional component, along with her expert knowledge, illustrates the profound impact she has on her patients and their families. Her ability to offer not just knowledge but also hope is what makes her an extraordinary caregiver. She continues to inspire those around her, and her innovative spirit in oncology research paves the way for the future of cancer care.

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