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Panelists discuss how quality of life priorities shift in late-line multiple myeloma treatment, with patients emphasizing the importance of maintaining independence in daily activities, preserving cognitive function, managing pain effectively, minimizing treatment-related side effects that impact social engagement, balancing treatment schedules to allow for meaningful family time and personal milestones and finding psychological peace through spirituality or support systems—ultimately revealing that while disease control remains critical, the ability to live with purpose and dignity increasingly shapes treatment decisions as patients progress through multiple therapy lines.

Aligning Treatment Goals: Key Considerations for Patients and Caregivers in Late-Line RRMM

Panelists discuss how balancing treatment effectiveness with quality of life in late-line multiple myeloma therapy requires a highly personalized approach, with patients and physicians collaboratively weighing factors such as potential for deeper or longer remissions against toxicity profiles, treatment logistics (inpatient vs. outpatient administration), impact on daily activities, financial toxicity, caregiver burden and individual patient goals, with many emphasizing that this calculus shifts as patients progress through treatment lines—often prioritizing aggressive approaches earlier while placing greater emphasis on maintaining functionality and meaningful life experiences in later treatment stages.

Balancing Efficacy and Quality of Life in Late-Line RRMM

Panelists discuss how physician-patient conversations about newer multiple myeloma therapies have evolved to include detailed discussions of potential benefits (higher response rates, novel mechanisms of action) alongside unique toxicity profiles (cytokine release syndrome with immunotherapies, neurotoxicity with CAR-T, skin/nail issues with GPRC5D-targeted agents), with patients sharing diverse experiences ranging from minimal side effects to significant complications that required hospitalization, emphasizing the importance of thorough preparation, proactive management strategies and realistic expectations when embarking on these innovative but potent treatment approaches.

Balancing Benefits and Risks: Patients’ Experiences With Newer Therapies and Side Effects in Late-Line RRMM

Panelists discuss how ciltacabtagene autoleucel (cilta-cel) demonstrates superior outcomes compared to real-world physician’s choice of therapy in patients with late-line relapsed/refractory multiple myeloma (RRMM), with significantly higher response rates, deeper remissions, longer progression-free survival and potentially improved overall survival, though they acknowledge the challenges of cross-trial comparisons and emphasize the importance of considering patient-specific factors such as fitness, prior therapy exposure and treatment goals when weighing this one-time cellular therapy against sequential conventional approaches.

Recent Updates in CAR-T Cell Therapy and Their Impact in Clinical Practice in RRMM

Panelists discuss how recent clinical trials have demonstrated promising outcomes in late-line relapsed/refractory multiple myeloma (RRMM) with bispecific antibodies targeting B-cell maturation antigen (BCMA) (teclistamab, talquetamab) and GPRC5D showing overall response rates of 60% to -70% even in heavily pretreated patients, while CAR-T cell therapies like ciltacabtagene autoleucel and idecabtagene vicleucel have produced deep responses with median progression-free survival extending beyond one year in some studies, and emerging combination approaches of these novel agents with traditional therapies are showing potential to overcome resistance mechanisms and improve durability of response.



Recent Updates in Bispecifics and Their Use in Clinical Practice

Panelists discuss how managing the logistics of multiple myeloma treatment often requires a comprehensive support network, with patients describing complex arrangements for travel to specialized cancer centers, securing temporary lodging near treatment facilities, coordinating caregiver schedules to ensure continual support during intensive therapy periods, navigating insurance and financial assistance programs, and utilizing hospital social workers, patient advocacy organizations and online communities to access resources that ease the burden of treatment-related logistics.

Managing Treatment Logistics: Navigating Travel, Lodging and Caregiver Support

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