QINLOCK may cause serious side effects, including:
A skin problem called palmar plantar erythrodysesthesia syndrome. Skin problems are common and sometimes can be severe. Tell your healthcare provider right away if you develop redness, pain, blisters, bleeding, or swelling on the palms of your hands or soles of your feet, or severe rash during treatment with QINLOCK.
New skin cancers. QINLOCK may cause skin cancers called cutaneous squamous cell carcinoma or melanoma. Talk to your healthcare provider about your risk for these cancers. Your healthcare provider should check your skin before and during treatment with QINLOCK to look for any new skin cancers.
Check your skin and tell your healthcare provider right away about any skin changes, including a:
High blood pressure (Hypertension). High blood pressure is common with QINLOCK and can be severe. Your healthcare provider should check your blood pressure regularly during treatment with QINLOCK.
Heart problems. Your healthcare provider should check you for signs or symptoms of heart failure before starting QINLOCK and regularly during treatment with QINLOCK. Heart failure can be serious and can sometimes lead to death. Tell your healthcare provider if you have any of the following symptoms during your treatment with QINLOCK:
Risk of wound healing problems. Wounds may not heal well during treatment with QINLOCK. Tell your healthcare provider if you plan to have any surgery before or during treatment with QINLOCK. Your healthcare provider should tell you when to stop taking QINLOCK before a planned surgery and when you may start taking QINLOCK again after surgery.
The most common side effects of QINLOCK include:
These are not all the possible side effects of QINLOCK.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088
It is not known if QINLOCK is safe and effective in children.
Before taking QINLOCK, tell your healthcare provider about all of your medical conditions, including if you:
For females, tell your healthcare provider if you:
For males with female partners who are able to become pregnant:
QINLOCK may affect fertility in males which may affect the ability to have children. Talk to your healthcare provider if this is a concern for you.
Tell your healthcare provider about all the medicines you take, including prescription and over the counter medicines, vitamins, and herbal supplements. QINLOCK and certain other medicines can affect each other causing side effects or affect how QINLOCK works.
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
General information about the safe and effective use of QINLOCK.
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use QINLOCK for a condition for which it was not prescribed. Do not give QINLOCK to other people, even if they have the same symptoms that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about QINLOCK that is written for health professionals.
What is QINLOCK?
QINLOCK is a prescription medicine used to treat adults with advanced gastrointestinal stromal tumor (GIST) who have received 3 or more prior treatments for their GIST.
Please see complete Prescribing Information, including Patient Information.
QINLOCK is a prescription medicine used to treat adults with advanced gastrointestinal stromal tumor (GIST) who have received 3 or more prior treatments for their GIST.
GIST basics: the disease and its challenges
Treatment options for advanced GIST
QINLOCK® (ripretinib): A different kind of TKI designed to treat advanced GIST
Services and resources to help you on your GIST journey
Arun Singh, MD
Ronald Reagon UCLA Medical Center
Sandra Brackert, NP
Ronald Reagon UCLA Medical Center
Sandra Brackert, NP: OK, let’s talk about treatment options for advanced GIST.
As you just heard Dr. Singh explain, the driving force in GIST are these tyrosine kinases—these proteins that have mutations on them.
There’s a very simple algorithm that we follow for the treatment of GIST, and the first-line treatment is imatinib, the second-line treatment is sunitinib, and the third-line treatment is regorafenib.
Another drug for advanced GIST is QINLOCK, or ripretinib. QINLOCK was recently approved as a fourth-line treatment.
There is another drug you’ll hear about that was also approved around the same time, called avapritinib.
When GIST advances to a certain point, unfortunately that’s a situation where you cannot remove it, and so we need a treatment that’s going to control the disease.
You’ll hear your care team use the words “stable disease”, or “progression-free survival”. This is actually good news. When we can find a treatment that keeps the disease from spreading to new areas, or the tumor itself from growing, or new tumors from popping up, we call it stable disease. That is when we know that we have control of the disease. Progression-free survival, or PFS, is the length of time, during and after cancer treatment, that a patient lives with the disease, but it does not get worse; that is, the tumor does not grow and the cancer does not spread to another part of the body.
We also want to make sure that the treatment is not worse than the disease. We want to make sure that we manage all your symptoms and side effects while you are on these treatments, so that you have the best quality of life, as well.
Q: So we get questions all the time, like what kind of side effects should I expect with TKIs?
A: Well, tyrosine kinase inhibitors may have some similar side effects, but each drug has its own unique set of side effects, and also, each person has their own unique side effects.
We really want you to share with your health care team whenever you get symptoms or have side effects because, quite honestly, we learn from you. A lot of the remedies and solutions that I’ll offer are based on what has and hasn’t worked for my other patients.
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DCPH-P00453 04/21