Senior medical oncologist and clinical lead for the Tumor Immunotherapy Program at the Princess Margaret Cancer Centre in Toronto, Ontario.

Dr Lillian Siu 

April is Head and Neck Cancer Awareness Month, and it is important to be aware of early signs and symptoms of the disease, as well as when to seek care.

Breaking Down Early Signs and Symptoms of Head and Neck Cancer

April is Head and Neck Cancer Awareness Month, according to the American Association for Cancer Research, and it is important to recognize that approximately 4% of all cancer in the United States make up head and neck cancers.

Moreover, the National Cancer Institute estimates that 71,110 people in the United States were diagnosed with head and neck cancer in 2024, whereas 16,110 patients died from the disease. Based on these numbers, it is important to stay aware of your risks for the disease and what symptoms of head and neck cancer may include, Dr. Lillian Siu emphasized in an interview with CURE

Siu, a senior medical oncologist and clinical lead for the Tumor Immunotherapy Program at the Princess Margaret Cancer Centre in Toronto, Ontario, sat down for an interview where she discussed the early signs and symptoms of head and neck cancer that patients should be aware of, as well as when they should seek medical attention.

Siu also serves as the director of the Phase I Program and co-director of the Bras and Family Drug Development Program at the Princess Margaret Cancer Centre, where she also holds the BMO Chair in Precision Genomics. Moreover, she is a professor of medicine at the University of Toronto.

This is a complex disease because head and neck cancer covers many anatomical sites, all the way from the oral cavity — from the front to the back — which is what we call the oropharynx, including areas like the tonsils, the base of the tongue and the bottom of the tongue. Then, you go further down into the larynx, which is our voice box, and even to what we call the hypopharynx, near the top of our esophagus.

All of that is part of the head and neck. Therefore, the symptoms vary quite a bit depending on where exactly the tumor starts. Generally, many of these patients present with a lump in the neck because the primary tumor has spread to the regional lymph nodes. Patients, while shaving or feeling their neck, notice a lump, and that is very often how they present.

Now, of course, if they have a tumor in the tongue, they may feel an abnormality, or their dentist may pick up something because they saw something during a dental checkup. If the tumor is in the larynx, they can present with hoarseness or changes in the quality of their voice. Therefore, it really depends on the site where it started.

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Articles

Head and neck cancers account for approximately 4% of all cancers in the United States, with an estimated 71,110 diagnoses and 16,110 deaths in 2024. These cancers encompass various anatomical sites, including the oral cavity, oropharynx, larynx, and hypopharynx, leading to diverse symptoms based on tumor location. Common presentations include neck lumps, voice changes, or oral abnormalities. Early detection is crucial, and individuals should be vigilant about symptoms and seek medical attention promptly. Dr. Lillian Siu emphasizes the importance of awareness and timely intervention.

Dr Lillian Siu

Breaking Down Early Signs and Symptoms of Head and Neck Cancer

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