CURE staff

At the CURE Educated Patient® Breast Cancer Summit, held live and virtually at the Miami Breast Cancer Conference, Dr. Anne O'Dea, medical director of breast cancer survivorship at the University of Kansas Medical Center, presented the keynote lecture, titled “A new era in the treatment of ER+, HER2- Advanced or Metastatic Breast Cancer: targeting ESR1 mutations.”

Educated Patient® Breast Cancer Summit at the Miami Breast Cancer Conference, held March 4, 2023.

In particular, O’Dea discusses the need for new endocrine therapies to treat estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as well as results from the EMERAL trial, that led to the Food and Drug Administration approval of elacestrant (Orserdu) in this patient population.

 O’Dea is a consultant and/or speaker for Gilead, DSI, Puma, Pfizer, Novartis and Stemline.

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Videos

Watch Dr. Anne O'Dea, from University of Kansas Medical Center, discuss targeting ESR1 mutations during the CURE Educated Patient® Breast Cancer Summit at MBCC.

Educated Patient® Breast Cancer Summit at MBCC Keynote Presentation: March 4, 2023

Fruits and vegetables are rich in antioxidants, vitamins, minerals and fiber, and they offer many protective health benefits to cancer survivors.

Summer is a great time of year to find fruits and vegetables in their prime, making recipes even more delicious and nutritious.

As part of its Heal at Home series, CURE® and its sister publication Heal® worked with registered dietitian Rachel Wong, of Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C., to compile multiple recipes for our readers.

From a tasty guacamole to a delicious chimichurri, below is a step-by-step guide to create these nutrient-packed sauces and dips that are sure to complement any dish this summer.

This take it easy tahini dressing with Mediterranean flair is great on salads, sandwiches, falafel pita, roasted vegetables and so much more.

This dressing with Mediterranean flair is great on salads, sandwiches, falafel pita, roasted vegetables and so much more.

Recipe adapted from themediterraneandish.com

1 to 2 garlic cloves (peeled and minced or crushed)

1/2 cup freshly squeezed lemon or lime juice

1 medium bunch of chopped cilantro or parsley, stems removed

Add all ingredients except the water to a food processer and blend.

Add a little bit of the water at a time and blend until the dressing reaches the desired consistency.

Transfer dressing to a serving bowl and enjoy!

Originating in South America, chimichurri typically is used on grilled meat but adds a flavor punch to salads, roasted vegetables, potatoes, rice and sandwiches.

Recipe adapted from feastingathome.com and Bon Appetit

1 shallot or ¼ cup red onion, finely chopped

1 Fresno chile or red jalapeño, finely chopped (optional)

3/4 cup extra-virgin olive oil plus more for desired consistency

Place shallot (or onion), chile (or jalapeño) and garlic in food processer and chop.

Add cilantro, oregano and parsley. Pulse again until mixed in well.

Transfer mixture to a medium bowl and add vinegar, lime juice, salt, pepper and ½ cup of the olive oil. Stir. Add in more salt and olive oil until desired consistency and taste.

Let mixture sit at least 10 minutes before serving. Chimichurri will keep up to 4 days in a sealed jar in the refrigerator.

Guacamole is always a favorite dip for chips, but try it on top of salads and burrito bowls.

2 dried chipotle chiles, finely crushed, stems discarded

2 diced medium avocados, pitted and skins removed

Heat olive oil in a medium skillet. Over medium heat, sauté shallot, crushed chipotle chiles and half of the tomatoes until softened, about 5 minutes. Season with salt. Place aside and allow to cool completely.

In a medium bowl, mix together avocados, onion, serrano chile, lime juice and remaining tomatoes. Add the cooled shallot mixture and fold in diced mango and chopped cilantro. Add salt to taste. Serve immediately.

Articles

As part of its Heal at Home series, CURE® worked with a registered dietitian from Georgetown Lombardi Comprehensive Cancer Center to put together several cancer-friendly dishes that everyone can enjoy this summer.

Cool Off From a Hot Summer With These Cancer-Friendly Recipes

A new vaccination immune response monitoring platform is going beyond a simple “Yes/No” and providing clinicians and patients more quantitative data regarding immune response to COVID-19 vaccination. The test could be especially beneficial for immunocompromised patients by informing timing for boosters down the road.

., just recently launched. Renold Capocasale, CEO and founder of FlowMetric, and Grant Morgan, PhD, PMP, executive vice president for FlowMetric and general manager of VaxEffect, spoke this week on the platform, its clinical application, and future plans for immune response tests for other vaccines beyond COVID-19.

“The VaxEffect test, built with different technology on flow cytometry, is able to actually detect not only were you infected with the COVID-19 virus or created an immune response to the vaccine, but also the level of immune response that you were able to generate in response to either prior infection or to the vaccine,” said Morgan.

What we're seeing with immunocompromised people, including people who have suffered from various different types of cancer, is that the immune response to the vaccine they receive is very varied. Some patients actually generate strong immune responses and, therefore, could be considered to be protected from the virus in going forward in their everyday lives.

But what they are seeing in both oncology specialties, but also for organ transplantation, diabetes, geriatric specialties, [is] that people have a reduced response to the vaccine they receive. And with regular serology tests not based on our platform of flow cytometry, they are actually getting results that say they are not generating any kind of immune response. But because the flow cytometry platform that we utilize for the VaxEffect test is so sensitive, we are actually able to identify a positive but weak immune response to the vaccine they received, which means there is a potential for a booster shot to actually increase that initial immune response that they generated.

VaxEffect is different to other tests on the market, specifically serology tests, in that a majority of them are over a very small dynamic range, which means that they can only give you really a qualitative result of ‘Yes, you've been infected or vaccinated and created an immune response,’ or ‘No, you haven't.’ The VaxEffect test, built with different technology on flow cytometry, is able to actually detect not only were you infected with the COVID-19 virus or created an immune response to the vaccine, but also the level of immune response that you were able to generate in response to either prior infection or to the vaccine.

The vaccine immune response monitoring platform can identify weak responses in patients with cancer and help determine the potential need for a booster shot.

VaxEffect Test Can Determine Immune Response to COVID-19 Vaccination in Patients With Cancer

Utilizing a dose escalation strategy, as well as preemptive use of a steroid cream and close follow-up within the first few months of initial treatment with Stivarga (regorafenib) may reduce side effects from the tyrosine kinase inhibitor (TKI) while improving quality of life, according to Dr. Tanios S. Bekaii-Saab.

Stivarga confers an improved survival benefit in patients with refractory metastatic colorectal cancer; however, side effects, like hand-foot skin reaction, may occur within the first two to three weeks after treatment initiation, with the most severe events occurring after week three or four. These common toxicities can be expected with oral TKIs, like Nexavar (sorafenib), but most of the toxicities tend to come a little bit later with those agents, Bekaii-Saab explained.

“The (idea) is, as you're starting the patient on treatment, those that are able to continue through it will see the benefits. Unfortunately, because of the early toxicities, a lot of patients end up stopping treatment prematurely, understandably so,” he added.

Hand-foot skin reaction, for example, causes redness, swelling and pain on the palms of the hands and/or the soles of the feet, which could limit walking or the use of one’s hands. “You can imagine that's incredibly disruptive,” said Bekaii-Saab, medical oncologist, leader of the Gastrointestinal Cancer Program at the Mayo Clinic Cancer Center, medical director of the Cancer Clinical Research Office and vice chair and section chief for medical oncology in the Department of Internal Medicine at the Mayo Clinic in Phoenix.

Therefore, he and his colleagues felt there was a need to determine ways to negate these toxicities so patients could stay on treatment with Stivarga in order to maximize the benefit of its improved survival outcomes.

“Most survival reported on this agent and similar agents is about six months, on average. In this case, you double the survival if you're able to get them to cycle three. So, we need strategies that mitigate some of the toxicities that ultimately have the patient stop the drug too prematurely and appear to negatively affect the overall outcome,” Bekaii-Saab said.

In the randomized, multicenter, open-label, phase 2 Regorafenib Dose Optimization Study (ReDOS) trial, the researchers evaluated four groups of patients treated with Stivarga:

54 patients were treated with a dose-escalation strategy: a starting dose of 80 mg per day orally, with weekly escalation of 40 mg each week, as tolerated, until a dose of 160 mg per day was reached.

62 patients were treated with a standard-dose strategy of 160 mg per day orally for 21 days of a 28-day cycle.

61 patients were preemptively treated with 0.05% clobetasol cream twice daily, applied to palms and soles before Stivarga treatment.

55 patients were reactively treated with 0.05% clobetasol cream twice daily, applied to palms and soles during Stivarga treatment.

They aimed to determine the proportion of patients who initiated cycle three of treatment.

After a median follow-up of 1.18 years, 23 patients (43%) treated with the dose escalation strategy and 16 patients (26%) treated with the standard dose initiated cycle three of treatment. The most common side effects experienced by those treated in the dose escalation and standard dosing strategies were fatigue (13% versus 18%, respectively), hand-foot skin reaction (15% versus 16%), abdominal pain (17% versus 6%) and hypertension (7% versus 15%). In addition, 14 patients had at least one drug-related serious side effect: six patients in the dose-escalation group and eight patients in the standard-dose group.

“With (dose escalation) by itself, it did not only improve the outcomes, meaning patients were more likely to stay on treatment, they're more likely to benefit from treatment and their survival was increased by an average of four months, at least,” Bekaii-Saab said. “But what we've seen also is a significant cut in toxicities as well as in the likelihood of the patients discontinuing treatment.”

When evaluating the use of clobetasol cream, 30% of those who followed the preemptive use strategy had no evidence of hand-foot skin reaction, compared with 13% who used the cream reactively during the first two cycles of treatment. During the first cycle, 54% and 45% of patients, respectively, had no hand-foot skin reaction, and 33% and 15% did not experience the side effect in the second cycle. During the second cycle, rates of grade 1, 2 and 3 hand-foot skin reaction were 30%, 8% and 3%, respectively, with preemptive clobetasol and 43%, 18% and 7%, respectively, with reactive clobetasol.

Moreover, patient-reported outcomes showed that the side effect compromised nearly all activities of daily living with worse quality of life in patients who received reactive versus preemptive clobetasol.

Bekaii-Saab noted that this finding has changed his practice in treating patients with Stivarga. “For many of my patients, now I do preemptive steroids. Ultimately, I think this is going to become a practice for every single one of our patients that goes on regorafenib,” he said. “We're even using it, based on this data, with other tyrosine kinase inhibitors. So this has expanded beyond regorafenib. This has changed, for all patients I hope, how we bring out some of these toxicities that can be incredibly limiting to quality of life.”

Ultimately, he added, the dose escalation strategy should be the standard of delivering Stivarga to patients, as well as the use of preemptive steroid creams. Lastly, Bekaii-Saab noted the importance of follow-up, in particular with the increased use of telemedicine following the COVID-19 pandemic.

“It has made it much easier for us to check on patients without bringing them to the clinic. The first month, my pharmacist, my nurse, and when possible myself, we get in touch with the patient,” he said, adding that follow-ups are the “third shield that will prevent those patients from going through a worse outcome.”

“They're already suffering from the cancer, we just want to make their lives better, not make it worse. And I think that if we don't do all the right things, we may actually impede their quality of life. If we do all the right things, then their quality of life is preserved and their survival is significantly improved. And they're more likely to get through more lines of therapy, which extends their survival significantly. So it's important. Cream, dose escalation strategy and close follow up are the three tenets of getting those patients through treatment.”

Although Stivarga may cause side effects after initial treatment, a dose escalation strategy and the preemptive use of steroid creams may help patients to tolerate the regimen better, while allowing them to capitalize on the agent’s survival benefit.

CURE staff

Educated Patient® Breast Cancer Summit at MBCC Keynote Presentation: March 4, 2023

Cool Off From a Hot Summer With These Cancer-Friendly Recipes

VaxEffect Test Can Determine Immune Response to COVID-19 Vaccination in Patients With Cancer

Three Tenets to Prevent Stivarga-Related Side Effects, Improve Survival and Quality of Life

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